Yondelis® (trabectedin) is a synthetic antineoplastic drug originally isolated from the marine tunicate Ecteinascidia turbinata. Trabectedin has a unique mechanism of action based on interaction with the minor groove of deoxyribonucleic acid (DNA), bending the helix to the major groove. This binding to DNA triggers a cascade of events affecting several transcription factors, DNA binding proteins, and DNA repair pathways, resulting in perturbation of the cell cycle.

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